Generalized fluid equations are derived by making an assumption for the shape of the velocity distribution function (VDF) and then taking velocity moments of the Boltzmann equation. How well the assumed VDF agrees with the actual VDF determines the accuracy of the resulting moment equations. Based on direct solutions to the Boltzmann equation for a fully ionized gas in the collision-dominated limit, we have assumed a shape for the VDF that is a Maxwellian with a third-order correction term. The resulting isotropic fluid equations for plasmas of arbitrary composition improve the description of collisional processes, particularly heat conduction and thermal forces, while retaining the relative simplicity of "conventional" fluid equations, allowing for easy implementation in numerical models. Expanding about a bi-Maxwellian results in gyrotropic transport equations that provide a good description of both collision-dominated and collisionless flow. We present results for the solar wind, where the equations have been implemented and solved numerically in a model extending from the chromosphere to Earth.